Various government and nongovernment organizations strongly oppose the use of animal experimentation for teaching purposes. Presentation Summary : Preliminary Industry Survey Results. (88 month(s) ago), Very good presentation! These training opportunities also serve as open forums for discussion of regulatory, compliance, and management issues. Ghosh; 2 nd Edn: Pg :3-15. Commonly used instruments in Experimental Pharmacology Ex-6 2. Embed: Introduction to experimental pharmacology. Human abuse potential laboratory studies. The articles, which describe OLAW's past and present interpretation and implementation of Policy provisions, provide a valuable source of information that demonstrates the historical evolution of Policy issues and methods proposed to address implementation and compliance. Handbook of Experimental Pharmacology . The first step of that organization toward meeting its charge was the production of the Handbook of Laboratory Animals (Herrlein et al., 1954), which summarized the state of the art in terms of genetic standards, nutrition, diseases, and uses of various laboratory animal species. H.Gerhard Vogel, 2 nd Edn; Pg:1371-1378 www.google.comPowerPoint Presentation: Thank you…………. For current rat information and links to many relevant Web sites, see the ILAR Home Page (http://www.nas.edu/ilar). Concerns regarding animal welfare and the growing awareness that policy development pertaining to laboratory animal science resulted in scientific progress led to the enactment of Republic Act 8485 in 1998, an Act to Promote Animal Welfare in the Philippines, otherwise known as “The Animal Welfare Act of 1998.”16 In 2013, Republic Act 1063117 was enacted amending certain sections of Republic Act 8485. Training workshops and symposia are offered regionally and are often cosponsored with organizations such as the Scientists Center for Animal Welfare (SCAW), the National Science Foundation (NSF), the Public Responsibility in Medicine and Research (PRIM&R), ARENA, the Animal Welfare Information Center (AWIC), the Institute for Laboratory Animal Research (ILAR), the American Association for Laboratory Animal Science (AALAS) and the American College of Laboratory Animal Medicine (ACLAM), in conjunction with state biomedical research association organizations and local academic institutions. Based on your opinion, S7A safety pharmacology endpoints in … AAALAC International is in a unique position to observe and benchmark the standards of laboratory animal care and use around the world given its presence in 34 countries. Regional Chapter Presidents’ Meeting PPT. Laboratory animal research in the Philippines started as early as the 18th century when Spanish conquistadors sent a mission to the country to study smallpox. Institutions that apply for AAALAC accreditation must provide a written program description covering: (1) institutional policies and responsibilities; (2) animal environment, housing, and management; (3) veterinary medical care; and (4) physical plant. 88–2959); and the “LAMA Disaster Preparedness Resource,” cosponsored by the Laboratory Animal Management Association and OLAW, are available on the OLAW Web site and are invaluable resources for institutional officials and support personnel when designing and managing their animal care and use programs. Typical experiments included effect of drugs on rabbit intestine, rabbit eye, central nervous system, reproductive system, as also the frog heart and frog rectus. Used in Experimental Pharmacology: In 1996, the name was changed to underscore that AAALAC International accredits institutional animal care and use programs around the world. For decades, scientists have used animals to carry out tests before they implement them on humans. Experimental animals received embelin (25 and 50 mg/kg, p.o.) (100 month(s) ago), hi i am suerprise about your well and good presentation, WELCOME: WELCOMEEXPERIMENTAL ANIMALS IN PHARMACOLOGY: EXPERIMENTAL ANIMALS IN PHARMACOLOGY Neena ThomasCONTENTS: CONTENTS INTRODUCTION EXPERIMENTAL ANIMALS HANDLING AND RESTRAINT DRUG ADMINISTRATION BLOOD COLLECTION CONCLUSION REFERENCESINTRODUCTION: INTRODUCTIONEXPERIMENTAL ANIMALS: EXPERIMENTAL ANIMALS Mice Rat Rabbit Guinea pig Hamster Dog Cat Monkey Frog BIOMETHODOLOGY OF MOUSE (mus musculus): BIOMETHODOLOGY OF MOUSE ( mus musculus) Order-RodentiaPowerPoint Presentation: GENERAL BIOLOGY Smaller docile Acute hearing, well developed sense of smell, poor vision & short generation interval circadian rhythm Swiss albino mouse - widely used strainBASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT:MALE 20-40 gm ADULTBODY WEIGHT:FEMALE 18-35 gm LIFE SPAN 1.5-3 yrs FOOD CONSUMPTION 15gm/100gm/day WATER CONSUMPTION 15ml/100gm/day BREEDING ONSET:MALE 50days BREEDING ONSET:FEMALE 50-60days GESTATION PERIOD 19-21days BODY TEMPERATURE 36-37 0 CPHYSIOLOGICAL DATA: PHYSIOLOGICAL DATA HEART RATE (beats/min) 330-780 RESPIRATORY RATE per min 84-230 TIDAL VOLUME (ml) 0.1-0.23 Hb(g/100ml) 10-19 RBC(million/mm 3 ) 4.9-12.5 WBC(thousands/mm 3 ) 4-12 BLOOD VOLUME(%B.W) 7-9HANDLING & RESTRAINT: HANDLING & RESTRAINT GENERAL PRINCIPLES: Use of proper restraint & handling techniques Acclimation period of upto 1 week Handle animals gently & firmly Use restraint devices when appropriate Chemical restraint for prolonged or potentially painful procedures MICE: MICE Grasp the middle of the tail between the thumb & index finger,& lift the mousePowerPoint Presentation: HOW TO PICK UP A MOUSE WITH THUMP FORCEPS Forceps tip covered with rubber/polyethylene tubing Grasp the middle of the tail between the forceps Too much pressure avoidedFOR TREATMENTS & CLOSE EXAMINATIONS : FOR TREATMENTS & CLOSE EXAMINATIONS held by tail & placed on a rough surface Grasp the loose skin over neck & shoulder with the thump & fingersRESTRAINT DEVICES: RESTRAINT DEVICES adapted to the restraint devices regularly monitored access to food or water released from restraint devices at least daily easy to clean & provide adequate ventilationMOUSE RESTRAINER: MOUSE RESTRAINER Different types available Plexiglasses, plastic cones,etc.SEXING: SEXING distance from the anus & genital papilla is greater in malesEXPERIMENTAL USES: EXPERIMENTAL USES Acute toxicity studies Assay of insulin and analgesics in genetics and cancer research Testing of drug for teratogenicity BIOMETHODOLOGY OF RAT (rattus norvegicus) order-Rodentia: BIOMETHODOLOGY OF RAT (rattus norvegicus ) order-RodentiaPowerPoint Presentation: GENERAL BIOLOGY Albino rat - widely used 2 strains: wistar sprague dawleyBASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT:MALE 300-500 gm ADULT BODY WEIGHT:FEMALE 250-300gm LIFE SPAN 2-3.5 yrs FOOD CONSUMPTION 10gm/100gm/day WATER CONSUMPTION 10-12ml/100gm/day BREEDING ONSET:MALE 65-110days BREEDING ONSET:FEMALE 65-110days GESTATION PERIOD 21-23days BODY TEMPERATURE 38-39 0 CPHYSIOLOGICAL DATA: PHYSIOLOGICAL DATA HEART RATE (beats/min) 300-500 RESPIRATORY RATE per min 65-180 TIDAL VOLUME (ml) 1.5 Hb(g/100ml) 12-17.5 RBC(million/mm 3 ) 7.2-9.6 WBC(thousands/mm 3 ) 6-12 BLOOD VOLUME(%B.W) 6-7HANDLING & RESTRAINT: HANDLING & RESTRAINT Grasp the base of tail wit thumb & forefinger FOR HEAVY RATS FOR SMALL RATSFOR CLOSE TREATMENTS/EXAMINATIONS: FOR CLOSE TREATMENTS/EXAMINATIONS Grasp the whole body with palm over the back & restrain forelimbs. 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